The usage of Casson tri hybrid nanofluids improves the fuel efficiency and engine operation in automobile engineering, and cooling techniques used for food preservation and processing. This gives an awareness for energy storage systems, heat exchangers and other industrial applications. Current investigation aims to address the consequences of heat generation with thermal slip effects on a steady, incompressible, two-dimensional, laminar flow of tri-hybrid nanofluid over a flat stretching sheet. The resultant nonlinear and highly complicated physical flow is explained by utilizing a Matlab-based robust Runge-Kutta-4 scheme. For higher values of volumetric fraction, the fluid motion decelerated whereas, the concentration diffusion enhanced. By enhancing the volume fraction from 0.01 to 0.03 led to a uniformity in the con-centration profile and their interaction within the base fluid has profound effect. Magnifying the porosity number decelerated the tri hybrid Casson nanofluid flow. 20% of aluminium oxide and 40% of Cathode nanotubes in the base fluid enhances the heat transfer rate up to 36.35% which is a good result. Novelty of the existing study is to simplify the former study by considering porosity, heat generation and thermal slip parameters to produce a more refined tri-hybrid Casson nanofluid definition.