The current numerical study investigates the impacts of heat source and radiation effects on thermo-fluidic behavior of trihybrid Casson (TiO2+SiO2+Al2O3/C6H9NaO7) nanofluids over a linearly stretching sheet. The study not only explores a method to achieve superior heat conduction compared to hybrid nanofluids but also highlights the environmental purification potential, decomposition of destructive materials, and effective cooling capabilities offered by the considered nanoparticle combination. The governing equations were converted into ordinary differential equations and are then explained using Runge-Kutta scheme with a Shooting algorithm. The temperature profile shifts upwards and concentration gradient reduces for higher values of heat source and radiation. Nusselt number decreases by 23.52% when radiation doubles from 1 to 2. The uniqueness of the work lies in its generalization of previous studies by considering heat source, radiation, thermophoresis and Brownian motion effects over a linear stretching sheet leading to the achievement of an effective tri-hybrid nanofluid flow.