Waste sludge disintegration and bound water reduction was investigated by comparative chemical oxidation using calcium hypochlorite, hydrogen peroxide, peroxymonusulfate and peroxydisulfate in the study. Response surface methodology (RSM) with Box-Benhken Design (BBD) was used to determine operating parameters namely initial pH (2–10), oxidant dosage (5–85 mg/g TSS), and Fe2+ to oxidant ratio; 0.2-2) and disintegration time (20–100 min). According to ANOVA results, determination coefficient (R2) was found 93.2%, 76.3%, 84% and 84.8% for each oxidant, respectively. Under the optimum operating conditions, disintegration degree in terms of chemical oxygen demand (DDCOD) was calculated 11.09%, 5.23%, 10.75%, and 5.34%, respectively. Furthermore, bound water reduction (BWR) of waste sludge increased after the disintegration process, and 33.52%, 24.56%, 44.63% and 32.80% BWR values were obtained under the same operating conditions. Results show that the higher DDCOD and BWR values were achieved by calcium hypochlorite and peroxymonosulfate treatment.