The study analyzes exergy and energy by applying environment-friendly newly developed refrigerants. Initially, a thermodynamic model has been developed. Then, not only energy but also exergy have been investigated utilizing the model. Various environment-friendly refrigerants have been selected as working fluids to compare the effects of net work output, pump consumption, coolant flow rate, thermal efficiency, exergy efficiency, exergy destructions, condenser exergy reduction, and exergy efficiencies with various evaporator pressures. It has been found that R141b and R21 give the highest amount of thermal and exergy efficiency at low and high evaporator pressure respectively. Moreover, R141b gives the highest amount of pump consumption and net work output whereas; R124 gives the highest amount of coolant flow rates. Additionally, R141b and R21 refrigerants give the highest amount of evaporator and condenser exergy efficiency respectively. On the contrary, R124 refrigerant gives the highest amount of expander exergy efficiency. In this paper, analysis has been done for various environment-friendly newly developed refrigerants which are very rare in the literature. The paper contributes significant impacts for reducing environmental emissions and improving organic Rankine cycle systems.