In recent years, many experimental and numerical studies have carried out to design structures resistant to high temperature effects caused by events such as fire. Reinforced concrete structures exposed to high temperature effects due to events such as fire, etc., also exposed to cyclic loading effects such as earthquakes during their lifetime. This study numerically investigates the behaviour of reinforced concrete frame members under cyclic lateral loading after exposure to high temperature effects In this context, 13 reinforced concrete frame members were modelled with the ABAQUS program and analysed under cyclic lateral loading after being exposed to 200, 400, 600 and 800 °C for 60, 120 and 180 minutes. Because of the thermo-mechanical analysis, the lateral load - horizontal displacement relationship and stiffness - horizontal displacement relationship of the reinforced concrete frames compared with the reference element that not exposed to high temperature effect. The results obtained confirm that the lateral load and stiffness capacities obtained from thermo-mechanical analysis with the CDP material model in ABAQUS are in good agreement with the experimental results. The use of the degree of high temperature and the duration of exposure as two variable parameters at the same time constitutes the main innovation that distinguishes the study from the literature. Because of the study, it recommended that reinforced concrete frames exposed to temperatures of 600 °C and above for 60, 120 and 180 minutes should not be use without strengthening. It thought that these suggestions would be useful to the reader in the rapid evaluation of fire-exposed reinforced concrete structural elements.