Plants have been used for medicinal purposes since ancient times. They include bioactive compounds, constitute the basis of the pharmaceutical industry. Origanum bilgeri includes bioactive compounds, display the significant biological activities. The present study includes the active ingredients used to stop the proliferation of gastric cancer and to prevent its spread with the effect of metastasis. In this study, the interaction of bioactive compounds found in Origanum bilgeri such as rosmarinic acid, transcinnamic acid, and resveratrol with gastric cancer receptors has been investigated by using docking, a chemical calculation method. Stomach cancer is a common disease among cancer types. The cause of this cancer is various factors, dietary habits and the foods taken are the leading ones. The interaction points will be determined by comparing the interaction of the active bioligands in these plants with the gastric cancer receptors with the foods taken, both as spices and as supplements. As a result of this study, it has been determined that the inhibitory effect of linalool (8-hydroxydihydro), Cinnamic acid, Resveratrol, Rosmarinic acid ligands in the Origanum medicine plant on gastric cancer receptors is quite high.