This study was carried out to determine the drinking water quality of İpsala, Keşan, Uzunköprü and Meriç Districts, which are located in the Meriç River Basin in Edirne Province of Turkey. Water samples were collected from 51 villages in autumn season of 2017. Some physical and chemical water quality parameters including dissolved oxygen, oxygen saturation, pH, electrical conductivity (EC), total dissolved solids (TDS), salinity, turbidity, nitrite (NO2), nitrate (NO3), phosphate (PO4) and cyanide (CN) were determined and the results were assessed according to national and international quality criteria. Pearson Correlation Index (PCI) and Principle Component Analysis (PCA) were applied to experimental data in order to determine the significant relations among the investigated parameters and effective factors on groundwater quality of the region. Geographic Information System (GIS) was also used in order to make a visual explanation by presenting distribution maps of investigated parameters. According to data observed, although the investigated parameter levels in drinking water of villages did not exceeded the limit values for drinking, the region has Class I – II water quality in terms of cyanide, nitrite and nitrate parameters; Class II – III in terms of electrical conductivity parameter; and Class III – IV in terms of phosphate parameter in general.