In this study; the contents of some trace elements (Mg, Al, Ca, Mn, Fe, Co, Ni, Cu, Zn, Se), toxic heavy metal contents (Cr, As, Cd) and lead isotopes (206Pb, 207Pb and 208Pb) were determined in some wild edible (Amanita caesarea (Scop.) Pers., Cantharellus cibarius Fr., Craterellus cornucopioides (L.) Pers., Fistulina hepatica (Schaeff.) With., Meripilus giganteus (Pers.) P. Karst) and cultivated mushroom (Agaricus bisporus (J.E. Lange) Imbach, Pleurotus ostreatus (Jacq.) P. Kumm.) species. The trace elements and toxic heavy metal contents were found lower than the upper limits in both wild edible mushrooms and cultivation mushrooms. The elemental composition of the wild mushrooms and the cultivated mushrooms obtained from different firms was found to be statistically different (p<0.05) from each other. C. cornucopioides was revealed with the highest Ca, Mn, Ni, Cu, Zn, 208Pb and Cr contents. The metal accumulation in wild mushrooms was higher than the cultivated mushrooms except Al and Se. All investigated parameters revealed that there was not any health risk associated with the consumption of the analyzed wild and cultivated mushrooms.