Synthesis of brominated quinolines
1Kırıkkale Üniversitesi, Eğitim Fakültesi, İlköğretim Bölümü, Fen Bilgisi Anabilim Dalı, KIRIKKALE
2ıldız Teknik Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, Davutpaşa-İSTANBUL
2ıldız Teknik Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, Davutpaşa-İSTANBUL
Sigma J Eng Nat Sci 2015; 33(1): 8-15
Abstract
In this study, bromination reactions of 1,2,3,4-tetrahydroquinoline by molecular bromine and aromatization reactions of brominated tetrahydroquinolines were reinvestigated. Optimal reaction conditions were established for 6-Bromo-1,2,3,4-tetrahydroquinoline (6-BrTHQ ) and 6,8-dibromo-1,2,3,4- tetrahydroquinoline (6,8-diBrTHQ). Improved yields and more shortened reaction times were described for the conversion of 6-BrTHQ and 6,8-diBrTHQ into 6-bromoquinoline and 6,8-dibromoquinoline.
Keywords: Quinoline, tetrahydroquinoline, bromoquinoline, bromination, aromatization, DDQ.
