Production and optimization method of smart hydrogels based on biocompatible polymer for controlled insulin release

OZGUNDUZ, Hediye Irem; KANDILCI, Hava Gizem; ACARALI, Nil; SARAC, Hanifi

Hediye Irem OZGUNDUZ ¹ , Hava Gizem KANDILCI ¹ , Nil ACARALI ¹ , Hanifi SARAC ¹

¹Yildiz Technical University, Chemical-Metallurgical Faculty, Chemical Engineering Department, Esenler- ISTANBUL

Sigma J Eng Nat Sci 2016; 34(1): 115-122

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Abstract

The aim of controlled insulin delivery study experiments is to produce the smart hydrogel to use insulin release for human body. Insulin entrapped p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragit L-100 were synthesized by using ammonium
persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker and new alternative ways were worked on to find and develop. Taguchi method was used and optimum synthesis conditions were determined. Insulin was entrapped into hydrogels as synthesis. After entrapped method,
loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.

Keywords: Hydrogel, insulin, Taguchi, Eudragit.