In this study, an inverse gas chromatography (IGC) study of thermodynamic interactions of a chalcone modified poly (styrene) based polymer (PVBC-DMAC) with some solvents was presented. For this purpose, the retention data of carefully selected polar and non-polar solvents on PVBC-DMAC was obtained by IGC instrument at temperatures between 358.2 𝐾 and 383.2 𝐾. Then, the polymer-solvent interaction parameters for Flory-Huggins theory, 𝜒12∞ and the equation of state theory, 𝜒12∗, the effective exchange energy parameters, 𝑋𝑒𝑓𝑓, the weight fraction activity coefficient, 𝛺1∞, and also the partial molar heat of mixing at infinite dilution of solvent, Δ𝐻̅1∞, the molar heat of vaporization of solvent, Δ𝐻𝑣, and the partial molar heat of sorption of solvent, Δ𝐻1𝑠 were calculated. The obtained results were discussed.